Parkinson's Disease
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Facts about Parkinson’s Disease:
Parkinson's disease (PD) belongs to a group of conditions called
motor system disorders, which are the result of the loss of
dopamine-producing brain cells. The four primary symptoms of PD are
tremor, or trembling in hands, arms, legs, jaw, and face; rigidity,
or stiffness of the limbs and trunk; bradykinesia, or slowness of
movement; and postural instability, or impaired balance and
coordination. As these symptoms become more pronounced, patients may
have difficulty walking, talking, or completing other simple tasks.
PD usually affects people over the age of 50.
Parkinson's disease is a disorder that affects nerve cells, or
neurons, in a part of the brain that controls muscle movement. In
Parkinson's, neurons that make a chemical called dopamine die or do
not work properly. Dopamine normally sends signals that help
coordinate your movements. No one knows what damages these cells
There are currently no blood or laboratory tests that have been
proven to help in diagnosing sporadic PD. Therefore the diagnosis is
based on medical history and a neurological examination. The disease
can be difficult to diagnose accurately. Doctors may sometimes
request brain scans or laboratory tests in order to rule out other
diseases.
Sources:
National Institute of Neurological Disorders and Stroke:
http://www.ninds.nih.gov/disorders/parkinsons_disease/parkinsons_disease.htm
MedlinePlus:
http://www.nlm.nih.gov/medlineplus/parkinsonsdisease.html
What are the causes of Parkinson’s Disease?
Parkinson's disease is caused by the progressive impairment or
deterioration of neurons (nerve cells) in an area of the brain known
as the substantia nigra. When functioning normally, these
neurons produce a vital brain chemical known as dopamine. Dopamine
serves as a chemical messenger allowing communication between the
substantia nigra and another area of the brain called the corpus
striatum. This communication coordinates smooth and balanced muscle
movement. A lack of dopamine results in abnormal nerve functioning,
causing a loss in the ability to control body movements.
In some cases, Parkinson's disease occurs within families,
especially when it affects young people. Most of the cases that
occur at an older age have no known cause.
While it is not clear what events cause the abnormal nerve
function linked to Parkinson's disease, there are certain conditions
and medications that can cause Parkinson's disease-like symptoms.
These include:
Certain medications. Certain drugs
such as antipsychotics used to treat severe paranoia and
schizophrenia can cause a person to experience symptoms that
resemble Parkinson's disease (Parkinsonism).
Shy-Drager syndrome. This is a rare
degenerative condition that produces symptoms similar to
Parkinson's disease.
Street drugs. MPTP, a synthetic heroin
contaminant, can cause severe Parkinson's disease-like symptoms.
Blood vessel disorders. Although rare,
stroke and atherosclerosis (hardening of the arteries) can cause
symptoms similar to Parkinson's disease.
Most researchers suggest that a combination of these factors may
cause the disease.
Sources:
WebMD:
http://www.webmd.com/parkinsons-disease/parkinsons-causes
MedlinePlus:
http://www.nlm.nih.gov/medlineplus/ency/article/000755.htm
What are the symptoms of Parkinson’s Disease?
The onset and symptoms of Alzheimer's disease are usually very
slow and gradual, seldom occurring before the age of 65. The diagnosis of Parkinson's Disease depends upon the presence of
one or more of the four most common motor symptoms of the disease,
which are: resting tremor, bradykinesia, rigidity and postural
instability.
In addition, there are other secondary and nonmotor symptoms that
affect many people and are increasingly recognized by doctors as
important to treating Parkinson’s.
Each person with Parkinson's will experience these symptoms
differently. For example, many people experience tremor as their
primary symptom, while others may not have tremors, but may have
problems with balance. Also, for some people the disease progresses
quickly, and in others it does not.
It occurs in the
following three stages:
Primary Motor Symptoms:
Resting Tremor: About 70 percent of people
with Parkinson’s experience a slight tremor in the early stage
of the disease - either in the hand or foot on one side of the
body, or less commonly in the jaw or face.
Bradykinesia (Slow Movement): Bradykinesia is
the phenomenon of a person experiencing slow movements.
Rigidity: Rigidity, also called increased
muscle tone, means stiffness or inflexibility of the muscles.
Postural Instability (Impaired Balance and
Coordination): People with Parkinson's disease often experience
instability when standing or impaired balance and coordination.
The secondary motor symptoms include dystonia, fatigue,
impaired gross motor coordination, sppech problems, difficulty
swallowing, sexual dysfunction, etc.
Nonmotor symptoms of Parkinson’s, such as sleep problems and
depression, can be, for many people, as troublesome as the primary
movement symptoms of the disease.
Sources:
Parkinson’s Disease Foundation:
http://www.pdf.org/en/symptoms
MedlinePlus:
http://www.nlm.nih.gov/medlineplus/parkinsonsdisease.html
What treatments are available for Parkinson’s Disease?
People who are only mildly affected by Parkinson's disease may
need no treatment at first. As symptoms progress, various treatment
approaches are available.
Medication selection and dosage are tailored to the
individual. The doctor considers factors such as severity of
symptoms, age and presence of other medical conditions. Every
patient responds differently to a medication or dosage level, so
this process involves experimentation, persistence, and patience. As
the disease progresses, drug dosages may need to be modified.
Sometimes drugs are combined. Patients need to receive care from
doctors who have extensive experience treating all stages of
Parkinson's disease - increasing the effectiveness of treatment at
every stage of the disease.
Surgical treatments such as ablation, deep brain stimulation,
and pallidotomy may control some symptoms.
Ablation - This procedure locates, targets, and then
ablates (destroys) a clearly defined area of the brain affected
by Parkinson's.
Deep Brain Stimulation (DBS) targets areas in the
brain where uncontrolled movements originate. The targeted
region is inactivated, not destroyed, by an implanted electrode.
Pallidotomy, (named for the pallidum area of the
brain) is a delicate surgical procedure that targets a precise
area to control certain symptoms.
Cerebral Transplantation - Dopamine-producing cells
are implanted into the brain. The cells used for transplantation
may come from fetal cells or embryonic stem cells.
Complementary Treatments - Numerous therapies and nutritional
supplements may help relieve symptoms and improve quality of life.
Physical therapy can help strengthen and tone underused muscles, and
give rigid muscles a better range of motion. The goal is to help
build body strength, improve balance, overcome gait problems and
improve speaking and swallowing.
Sources:
Mayoclinic:
http://www.mayoclinic.org/parkinsons-disease/treatment.html
WebMD:
http://www.webmd.com/parkinsons-disease/guide/parkinsons-disease-treatment-overview
HerbaCall Parkinson’s Disease Testimonials:
· Morgan Elser tells Herbacall, "My
father-in-law had advanced Parkinson's, was under weight with severe
tremors and was over 90 years old. We started him on Longetics or
Formula 1
2x a day, Formula 3 2x a day, vitamin C 4-5tabs a day. He gained
18lbs in the first 6 weeks, his tremors were much less severe and he
was more stable when he walked. It put roses back into his cheeks
and gave him a better quality of life."
· Cathryn said proudly, "As of 4 weeks ago
my neighbor started on products. He is 72 yrs. old and has had
Parkinson's for 6 yrs. now, is very thin due to weight loss from
disease, and for the last several yrs has walked like he was 101
yrs. old and stooped over. While he expressed concern about the
proteins (in
Formula 1), he just decided to try
them and in days he called me and said he was regular for the first
time in Yrs. and in about a week my husband and I couldn't believe
it - he was skipping around his yard. We always had to help him with
getting his mail and garbage - not anymore! He looks decades
younger!"
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